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Three years since the COVID-19 pandemic, it has become clear that a response strategy for the virus needs to be dynamic in nature. The everchanging nature of the virus and its numerous variants, each of them unique in severity and transmission, make it clear that working toward preparedness is more challenging than previously thought. This Gender Equality Update highlights the impact of COVID-19 on women and excluded groups, preparedness measures implemented by different bodies of the Government of Nepal, challenges faced while responding to the pandemic and recommendations to be considered for future planning.